CÂNCER NO IDOSO: REFLEXÕES SOBRE O ÔNUS DA IDADE.
Keywords:
Envelhecimento, Polifarmácia, Câncer, Toxicidade, Equipe MultiprofissionalAbstract
O complexo processo de envelhecimento, associado a alterações no sistema imunológico, desencadeia um aumento do risco de doenças. Em idosos, instabilidades genéticas com dano ao DNA podem induzir o desenvolvimento de câncer e, consequentemente, uma relação causal com aumento da mortalidade. Este artigo de revisão aborda tópicos sobre condições clínicas preexistentes associadas a um diagnóstico de câncer. Doenças cardiovasculares, depressão, demência e insuficiência renal podem ser potencializadas durante o tratamento do câncer, principalmente pela associação com toxicidade medicamentosa e polifarmácia. Aspectos nutricionais e hemodinâmicos também podem aumentar a relação com a toxicidade. Por outro lado, o cuidado de suporte para pacientes idosos com câncer aumenta a expectativa de vida e melhora a morbidade. Portanto, a equipe multiprofissional deve acompanhar esses indivíduos com intervenções que busquem melhorar as chances de redução da morbi-mortalidade, restaurando a qualidade de vida após o diagnóstico.
References
- Jaul, E.; Barron, J. Age-Related Diseases and Clinical and Public Health Implications for the 85 Years Old and Over Population Mini Review ARTICLE Front. Public Health11 December2017https://doi.org/10.3389/fpubh.2017.00335
- Koll, T.; et al. Supportive Care in Older Adults with Cancer: Across the Continuum. Curr Oncol Rep. 2016 August; 18(8): 51. doi:10.1007/s11912-016-0535-8.
- Obst L. O que você vai ser quando envelhecer? Instituto de Longevidade. 1 edição. Palhoça. Editora UNISUL.2017. 220p.
- https://www.un.org/en: nacoesunidas.org/acao/pessoas-idosas. Accessed in 12/06/2020.
- Navaratnarajah, A.; Jackson, SHD. The physiology of aging. Medicine in older adults. 2016, p 6-10.
- Bray, F.; et al. Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA CANCER J CLIN 2018; 68:394–424. Volume 68, Number 6, November/December 2018
– Calcinotto A, Kohli J, Zagato E, Pellegrini L, Demaria M, Alimonti A. Cellular Senescence: Aging, Cancer, and Injury. Physiol Rev. 2019 Abr 1;99(2):1047-1078. doi: 10.1152/physrev.00020.2018. 30648461.
- Nicolás Herranz and Jesús Gil. Mechanisms and functions of cellular senescence. J Clin Invest. 2018 Apr 2;128(4):1238-1246. DOI: 10.1172/JCI95148. Epub 2018 Apr.
- https://www.paho.org/pt/topicos/cancer, acesso em 11/08/2021.
- Wang L, Baser O, Kutikova L, Page JH, Barron R. The impact of primary prophylaxis with granulocyte colony-stimulating factors on febrile neutropenia during chemotherapy: a systematic review and meta-analysis of randomized controlled trials. Support Care Cancer. 2015; 23(11): 3131–40. DOI: 10.1007/s00520-015-2686-9 [PubMed: 25821144]
– Gewandter JS, Fan L, Magnuson A, Mustian K, Peppone L, Heckler C, et al. Falls and functional impairments in cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN): a University of Rochester CCOP study. Support Care Cancer. 2013; 21(7):2059–66. DOI: 10.1007/ s00520-013-1766-y [PubMed: 23446880]
- Wastesson, JW.; et al. An update on the clinical consequences of polypharmacy in older adults: a narrative review. Journal Expert Opinion on Drug Safety. Vol 17, 2018- Issue12.https://doi.org/10.1080/14740338.2018.1546841
– National Comprehensive Cancer Network (NCCN). Acesso 05/2020 Cancer- and chemotherapy-induced anemia. NCCN Guidelines and National Comprehensive Cancer Network (NCCN). Older adult oncology. 2016. Accessed in 10/04/2020.
- Molassiotis A, Aapro M, Dicato M, Gascon P, Novoa SA, Isambert N, et al. Evaluation of risk factors predicting chemotherapy-related nausea and vomiting: results from a European prospective observational study. J Pain Symptom Manage. 2014; 47(5):839–48. DOI: 10.1016/j.jpainsymman. 2013.06.012.e4 [PubMed: 24075401]
- Todd A, Williamson S, Husband A, Baqir W, Mahony M. Patients with advanced lung cancer: is there scope to discontinue inappropriate medicati. International Journal of Clinical Pharmacy 35(2) · December 2012. DOI: 10.1007/s11096-012-9731-2 · Source: PubMed
- Cappellani A, Di Vita M, Zanghi A, Cavallaro A, Piccolo G, Veroux M, Berretta M, Malaguarnera M, Canzonieri V, Lo Menzo E (2012). «Diet, obesity and breast cancer: an update». Front Biosci (Schol Ed). 4: 90–108. PMID 22202045.
- Lilamand M, Kelaiditi E, Cesari M, Raynaud-Simon A, Ghisolfi A, Guyonnet S, et al. Validation of the Mini Nutritional Assessment-Short Form in a population of frail elders without disability. Analysis of the Toulouse Frailty Platform Population in 2013. J Nutr Health Aging. 2015; 19(5): 570–4. DOI: 10.1007/s12603-015-0457-4 [PubMed: 25923488]
- Gewandter JS, Fan L, Magnuson A, Mustian K, Peppone L, Heckler C, et al. Falls and functional impairments in cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN): a University of Rochester CCOP study. Support Care Cancer. 2013; 21(7):2059–66. DOI: 10.1007/ s00520-013-1766-y [PubMed: 23446880]
- Multinational association for supportive care in cancer. What is MASCC. http://www.mascc.org/about-mascc 3. Accessed in 15/07/2020.
- Saracino RM, Weinberger MI, Roth AJ, Hurria A, Nelson CJ. Assessing depression in a geriatric cancer population. Psychooncology. 2017 Oct;26(10):1484-1490. doi: 10.1002/pon.4160. Epub 2016 May 16. PMID: 27195436; PMCID: PMC5112141.
- National Cancer Institute. Dictionary of cancer terms—supportive care. HTTP:// www.cancer.gov/publications/dictionaries/cancer-terms?cdrid=46609 2. Accessed in 10/07/2021
- Maggiore RJ, Dale W, Gross CP, Feng T, Tew WP, Mohile SG, et al. Polypharmacy and potentially inappropriate medication use in older adults with cancer undergoing chemotherapy: effect on chemotherapy-related toxicity and hospitalization during treatment. J Am Geriatr Soc. 2014; 62(8):1505–12. DOI: 10.1111/jgs.12942 [PubMed: 25041361]
- Nightingale G, Hajjar E, Swartz K, Andrel-Sendecki J, Chapman A. Evaluation of a pharmacistled medication assessment used to identify prevalence of and associations with polypharmacy and potentially inappropriate medication use among ambulatory senior adults with cancer. J Clin Oncol. 2015; 33(13):1453–9. A key study documenting the important role of the pharmacist in a senior adult oncology clinic. DOI: 10.1200/JCO.2014.58.7550 [PubMed: 25800766].
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