OCORRÊNCIA DE DOENÇAS AUTOIMUNES EM PACIENTES COM SÍNDROME DE DOWN ATENDIDOS NO AMBULATÓRIO DE SÍNDROME DE DOWN DA FURB – BLUMENAU – AVALIAÇÃO DE 2001 A 2014
DOI:
https://doi.org/10.63845/3tc6ax23Keywords:
Síndrome de Down, Doenças autoimunes, Doença de Hashimoto, Doença de Graves, Doença CelíacaAbstract
Quando comparados com a população em geral, pacientes com Síndrome de Down (SD) expressam maior risco para o desenvolvimento de doença autoimune (DAI). Este estudo teve como objetivo a avaliação da ocorrência de DAI em pacientes com SD. Trata-se de estudo retrospectivo. Foram avaliados 122 prontuários de pacientes atendidos no Ambulatório de SD da Universidade Regional de Blumenau. As patologias pesquisadas e os critérios utilizados para diagnóstico das mesmas foram: Tireoidite de Hashimoto (TH) - TSH elevado, presença de anticorpos anti-tireoideanos e ultrassonografia confirmatória; Doença de Graves (DG) - TSH baixo com presença de anticorpo anti-receptor de TSH; Doença Celíaca (DC) - Anticorpo anti-endomíseo IgA positivo e/ou anti-transglutaminase com biópsia característica; Alopecia Areata (AA) e Vitiligo - avaliação dermatológica e Diabetes Mellitus tipo I (DMI) - Anticorpo anti-GAD (ácido glutâmico descarboxilase) positivo e hiperglicemia. A ocorrência de DAI foi de 18,85%. TH foi encontrada em 13 pacientes, DC em 5 pacientes, DG em 4 pacientes, AA em 2 pacientes, vitiligo em 1 paciente, nenhum paciente teve diagnóstico de DMI. A prevalência de DAI neste estudo foi concordante com a literatura mundial. Recomenda-se rastreio regular destas doenças nos pacientes com SD.References
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