TESTES DE FUNÇÃO PULMONAR EM NEONATOS, LACTENTES, CRIANÇAS e ADOLESCENTES COM FIBROSE CÍSTICA
REVISÃO SISTEMÁTICA
DOI:
https://doi.org/10.63845/tkd3ma21Palavras-chave:
Fibrose Cística. Recursos e técnicas fisioterapêuticas. Fisioterapia respiratória, teste de função pulmonar, pediatriaResumo
Introdução: A fibrose cística (FC) é uma doença genética que acomete principalmente os pulmões, afetando assim sua função. Os testes de função pulmonar (TFP) são capazes de detectar a doença desde os primeiros dias de vida, além de verificarem alterações no sistema respiratório, sendo importantes marcadores clínicos na identificação, diagnóstico e acompanhamento. Objetivo: Verificar sistematicamente na literatura os TFP utilizados em neonatos, lactentes e crianças com FC. Métodos: Busca sistemática nas bases de dados Embase, Pubmed, Web of Science e Scopus, utilizando descritores específicos (“Cystic Fibrosis”, “Pulmonary Functional Tests”, “Newborn”, “Child”, “Infant) e seus correlatos. A revisão foi realizada de acordo com o checklist Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), utilizado para o processo de seleção de estudos. A avaliação da qualidade metodológica foi realizada por meio da Ferramenta de Avaliação da Qualidade para Coortes Observacionais e Transversais (NHLBI) para estudos observacionais. Resultados: Foram identificados 3.812 estudos, sendo ao final, selecionados 14. Os estudos foram predominantemente observacionais, sendo somente um, ensaio clínico. A amostra foi constituída de indivíduos de quatro semanas a dez anos de idade. A espirometria foi o TFP mais relatado nos estudos, também foram reportados a Pletismografia, Multiple breath washout, Raised volume rapid thoracic compression technique. A maioria dos estudos apresentou boa qualidade metodológica. Conclusão: A identificação precoce da FC exige que avaliações e acompanhamentos sejam realizados logo após o diagnóstico. Os TFP configuram importantes ferramentas para o manejo adequado das alterações respiratórias nessa população.
Referências
Naehrig S, Chao C, Naehrlich L. Cystic Fibrosis. Deutsches Arzteblatt International. 2017, 114(34): 564-574. DOI: https://doi.org/10.3238/arztebl.2017.0564
Knowles MR. et al. Abnormal respiratory epithelial ion transport in cystic fibrosis. Clinics in Chest Medicine. 1986, 7(2): 285-297. DOI: https://doi.org/10.1016/S0272-5231(21)00424-X
Elborn JS. Cystic fibrosis. The Lancet. 2016, 388(10059): 2519-2531. DOI: https://doi.org/10.1016/S0140-6736(16)00576-6
Ockenga J, Stuhrmann M, Manns MP. Evaluation of the role of CFTR in alcohol related pancreatic disease. Gut. 2001, 49(2):312-313. DOI: https://doi.org/10.1136/gut.49.2.312a
Duncan JA, Aurora P. Monitoring early lung disease in cystic fibrosis. Breathe. 2014, 10(1): 34-47. DOI: https://doi.org/10.1183/20734735.010813
Beydon N. et al. An Official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool children. American Journal of Respiratory and Critical Care Medicine. 2007,175(12): 1305-1344. DOI: https://doi.org/10.1164/rccm.200605-642ST
Galvão TF, Pansani TSA, Harrad D. Principais itens para relatar revisões sistemáticas e meta-análises: a recomendação PRISMA. Epidemiologia e Serviços de Saúde.2015, 24(2): 335-342. DOI: https://doi.org/10.5123/S1679-49742015000200017
Qatar Computing Research Institute. Hamad Bin Khalifa University. Disponível em: <https://rayyan.qcri.org/>.
Méndez-Bustos P. et al. Effectiveness of psychotherapy on suicidal risk: a systematic review of observational studies. Frontiers in Phychology. 2019, 10(277): 1-10. DOI: https://doi.org/10.3389/fpsyg.2019.00277
Muniz-Pardos BP. et al. Swim-Specific Resistance Training: A Systematic Review. The Journal of Strength and Conditioning Research. 2019, 33(10): 2875-2881. DOI: https://doi.org/10.1519/JSC.0000000000003256
Yanaz M, Yegit CY, Gulieva A. et al. Electronic home monitoring of children with cystic fibrosis to detect and treat acute pulmonary exacerbations and its effect on 1-year FEV 1. Journal of Cystic Fibrosis, 23 (2024): 329–333. DOI: https://doi.org/10.1016/j.jcf.2023.09.007
Athanazio RA. et al. Diretrizes brasileiras de diagnóstico e tratamento da fibrose cística. Jornal Brasileiro de Pneumologia. 2017, 43(3): 219-245.
Rayment JH. et al. Lung clearance index to monitor treatment response in pulmonary exacerbations in preschool children with cystic fibrosis. Thorax. 2018,73(5): 451-458. DOI: https://doi.org/10.1136/thoraxjnl-2017-210979
Stanojevic S. et al. Progression of lung disease in preschool patients with cystic fibrosis. American Journal of Respiratory and Critical Care Medicine. 2017, 195(9):1216-1225. DOI: https://doi.org/10.1164/rccm.201610-2158OC
BRITTON, L. J. et al. Risk stratification model to detect early pulmonary disease in infants with cystic fibrosis diagnosed by newborn screening. Pediatric Pulmonology, v. 51, n. 11, p. 1168-1176, 2016. DOI: https://doi.org/10.1002/ppul.23536
BRUMBACK, L. C. et al. Lung function from infancy to preschool in a cohort of children with cystic fibrosis. European Respiratory Journal, v. 41, n. 1, p. 60-66, 2013. DOI: https://doi.org/10.1183/09031936.00021612
ROSENFELD, M. et al. An Official American Thoracic Society workshop report: optimal lung function tests for monitoring cystic fibrosis, bronchopulmonary dysplasia, and recurrent wheezing in children less than 6 years of age. American Thoracic Society Documents, v. 10, n. 2, p. 1-11, 2013. DOI: https://doi.org/10.1513/AnnalsATS.201301-017ST
DAVIS, S. D. et al. Multicenter evaluation of infant lung function tests as cystic fibrosis clinical trial endpoints. American Journal of Respiratory and Critical Care Medicine, v. 182, n. 11, p. 1387-1397, 2010 DOI: https://doi.org/10.1164/rccm.200908-1236OC
KORTEN, I. et al. Respiratory rate in infants with cystic fibrosis throughout the first year of life and association with lung clearance index measured shortly after birth. Journal of Cystic Fibrosis, v. 18, n. 1, p. 118-126, 2018. DOI: https://doi.org/10.1016/j.jcf.2018.07.002
DAVIES, G. et al. Pulmonary function deficits in newborn screened infants with cystic fibrosis managed with standard UK care are mild and transient. European Respiratory Journal, v. 50, n. 5, p. 1-9, 2017. DOI: https://doi.org/10.1183/13993003.00326-2017
NGUYEN, T. T. D. et al. Evolution of lung function during the first year of life in newborn screened cystic fibrosis infants. Thorax, v. 69, n. 10, p. 910-917, 2014. DOI: https://doi.org/10.1136/thoraxjnl-2013-204023
AURORA, P. et al. Lung clearance index at 4 years predicts subsequent lung function in children with cystic fibrosis. American Journal of Respiratory and Critical Care Medicine, v.183, n. 6, p. 752-758, 2011. DOI: https://doi.org/10.1164/rccm.200911-1646OC
HARDAKER, K. M. et al. Abnormal preschool Lung Clearance Index (LCI) reflects clinical status and predicts lower spirometry later in childhood in cystic fibrosis. Journal of Cystic Fibrosis, v. 18, n. 5, p. 721-727, 2019. DOI: https://doi.org/10.1016/j.jcf.2019.02.007
CAUDRI, D. et al. The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis. Journal of Cystic Fibrosis, v. 17, n. 4, p. 462-469, 2018. DOI: https://doi.org/10.1016/j.jcf.2017.12.002
LUMERTZ, M. S. et al. Comparação entre a evolução de pré-escolares com fibrose cística identificados por triagem neonatal ou por sintomatologia clínica. Scientia Medica, v. 28, n. 2, p. 1-6, 2018. DOI: https://doi.org/10.15448/1980-6108.2018.2.29566
Kniphoff GJ, Silva MR, Cardoso MCAF. VALORES DA CAPACIDADE RESPIRATÓRIA DE CRIANÇAS HÍGIDAS: Revisao sistemática. Ciencias da saúde. 2024, 16 (2): 86-98.
MOHER, D. et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Annals of Internal Medicine, v. 151, n. 4, p. 264-269, 2009. DOI: https://doi.org/10.7326/0003-4819-151-4-200908180-00135
Ducati GC, Cardoso J, Ferrazeane EP, Schivinski CIS. Respiratory system parameters in children with low severity cystic fibrosis: is there early involvement in relation to healthy peers? Healthy and cystic fbrosis lung variables in children. Rev Paul Pediatr. 2024;42:e2023030. DOI: https://doi.org/10.1590/1984-0462/2024/42/2023030
Marchis M, Montemitro E, Boni A et al. Lung clearance index short-term variability in cystic fibrosis: a pre-post pulmonar exacerbation study. Page 2 of 7Marchis De et al. Italian Journal of Pediatrics (2024) 50:6 pag 2-7. DOI: https://doi.org/10.1186/s13052-023-01574-w
DINWIDDIE, R. Lung function in paediatrics. Lung function testing in children. Allergologia et Immunopathologia, v. 32, n. 2, p. 88-91, 2010. DOI: https://doi.org/10.1016/j.aller.2009.11.003
SARAYKA, A. et al. Evaluation of children with cystic fibrosis by impulse oscillometry when stable and at exacerbation. Pediatric Pulmonology, v. 51, n. 11, p. 1151-1158, 2016. DOI: https://doi.org/10.1002/ppul.23449
KOMAROW. et al. Impulse oscillometry in the evaluation of diseases of the airways in children. Annals of Allergy, Asthma and Immunology, v. 106. n. 3, p. 191-199, 2011. DOI: https://doi.org/10.1016/j.anai.2010.11.011
GRAHAM, B. L. et al. Standardization of spirometry 2019 update. An official American Thoracic Society and European Respiratory Society technical statement. American Journal of Respiratory and Critical Care Medicine, v. 200, n. 8, p. 70-88, 2019. DOI: https://doi.org/10.1164/rccm.201908-1590ST
ROBINSON, P. D. et al. Preschool Multiple-Breath Washout Testing. American Thoracic Society Documents, v. 197, n. 5, p. 1-19, 2018. DOI: https://doi.org/10.1164/rccm.201801-0074ST
ROSENFELD, M. et al. Association of lung function, chest radiographs and clinical features in infants with cystic fibrosis. European Respiratory Journal, v. 42, n. 6, p. 1-14, 2013. DOI: https://doi.org/10.1183/09031936.00138412
JONES, M. H. et al. Valores de referência de espirometria para crianças brasileiras. Jornal Brasileiro de Pneumologia, v. 46, n. 3, p. 1-8, 2020. DOI: https://doi.org/10.36416/1806-3756/e20190138
SUBBARAO, P. et al. Comparison of spirometric reference values. Pedriatric Pulmonology, v. 27, n. 6, p. 515-522, 2014. DOI: https://doi.org/10.1002/ppul.20015
SIMPSON, S. J. et al. Progressive ventilation inhomogeneity in infants with cystic fibrosis after pulmonary infection. European Respiratory Journal, v. 46, n. 6, p. 1680-1690, 2015. DOI: https://doi.org/10.1183/13993003.00622-2015
FRETZAYAS, A. et al. Applications of lung clearance index in monitoring children with cystic fibrosis. World Journal Of Clinical Pediatrics, v. 8, n. 2, p. 15-22, 2019. DOI: https://doi.org/10.5409/wjcp.v8.i2.15
STAHL, M. et al. Three-center feasibility of lung clearance index in infants and preschool children with cystic fibrosis and other lung diseases. Journal of Cystic Fibrosis, v. 17, n. 2, p. 249-255, 2018 DOI: https://doi.org/10.1016/j.jcf.2017.08.001
STOCKS, J. et al. Plethysmographic measurements of lung volume and airway resistance. European Respiratory Journal, v. 17, n. 6, p. 302-312, 2001. DOI: https://doi.org/10.1183/09031936.01.17203020
STOCKS, J.; THIA, L. P.; SONNAPPA, S. Evaluation and use of childhood lung function tests in cystic fibrosis. Current Opinion in Pulmonary, v. 18, n. 6, p. 602-608, 2012. DOI: https://doi.org/10.1097/MCP.0b013e328358dfbe
VERA, T. N.; PINTO, L. A. Viabilidade da realização de espirometria em pré-escolares. Jornal Brasileiro de Pneumologia, v. 37, n. 1, p. 69-74, 2011. DOI: https://doi.org/10.1590/S1806-37132011000100011
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Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
