A RELAÇÃO ENTRE SONO E EPILEPSIA: UMA REVISÃO SOBRE O TEMA

Autores

  • Aline Vieira Scarlatelli Lima
  • Lucia Sukys Claudino
  • Katia Lin

Palavras-chave:

Epilepsia, Sono, Transtornos do sono, Anticonvulsivantes

Resumo

A relação entre sono e epilepsia é mútua e complexa. O sono é um conhecido ativador de crises e paroxismos epileptiformes, como pode ser observado em algumas síndromes epilépticas em que há um nítido padrão de distribuição das crises relacionado ao ciclo sono-vigília. Além do mais, a epilepsia e seus tratamentos têm efeitos sobre o sono, alterando sua estrutura e provocando sua fragmentação.

Pacientes com epilepsia possuem maior prevalência de sonolência diurna e de distúrbios do sono. Esses distúrbios resultam em piores índices de qualidade de vida quando comparados àqueles que não apresentam tais comorbidades. Dentre os distúrbios do sono que estão associados à epilepsia, o mais estudado é a síndrome da apneia e hipopneia obstrutiva do sono. O tratamento dessa síndrome melhora a sonolência excessiva diurna nos PCE além de melhorar o controle de crises nos pacientes resistentes às medicações antiepilépticas.

O objetivo do presente artigo é revisar a interação entre o sono e epilepsia, destacando sua relação recíproca, além de abordar a prevalência e os efeitos do tratamento dos distúrbios do sono nos pacientes com epilepsia.

Biografia do Autor

  • Aline Vieira Scarlatelli Lima
    Médica Neurologista e Neurofisiologista Clínica. Universidade do Sul de Santa Catarina
  • Lucia Sukys Claudino
    Neurologista e Neurofisiologista Clínica do Serviço de Neurologia, Departamento de Clínica Médica, HU-UFSC.
  • Katia Lin
    Profa. Adjunta do Serviço de Neurologia, Departamento de Clínica Médica, HU-UFSC

Referências

Gowers, WR. Epilepsy and other chronic convulsive diseases: their causes, symptoms and treatment. New York : William Wood & Company; 1885.

Derry CP, Duncan S. Sleep and epilepsy. Epilepsy Behav 2013; 26:394-404.

Bazil CW, Castro LH, Walczak TS. Reduction of rapid eye movement sleep by diurnal and nocturnal seizures in temporal lobe epilepsy. Arch Neurol 2000; 57:363-8.

Zanzmera P, Shukla G, Gupta A, et al. Effect of successful epilepsy surgery on subjective and objective sleep parameters--a prospective study. Sleep Med 2013; 14:333-8.

Li P, Ghadersohi S, Jafari B, et al. Characteristics of refractory vs. medically controlled epilepsy patients with obstructive sleep apnea and their response to CPAP treatment. Seizure 2012; 21:717-21.

Manni R, Terzaghi M, Arbasino C, et al. Obstructive sleep apnea in a clinical series of adult epilepsy patients: frequency and features of the comorbidity. Epilepsia 2003; 44:836-40.

Manni R, Terzaghi M. Comorbidity between epilepsy and sleep disorders. Epilepsy Res 2010; 90:171-7.

Pornsriniyom D, Shinlapawittayatorn K, Fong J, et al. Continuous positive airway pressure therapy for obstructive sleep apnea reduces interictal epileptiform discharges in adults with epilepsy. Epilepsy Behav 2014; 37:171-4.

Vaughn BV, Ali I. Sleep and epilepsy: opportunities for diagnosis and treatment. Neurol Clin 2012; 30:1249-74.

Dewolfe JL, Malow B, Huguenard J, et al. Sleep and epilepsy: a summary of the 2011 merritt-putnam symposium. Epilepsy Curr 2013;13:42-9.

Crespel A, Coubes P, Baldy-Moulinier M. Sleep influence on seizures and epilepsy effects on sleep in partial frontal and temporal lobe epilepsies. Clin Neurophysiol 2000; 111 Suppl 2:S54-9.

Serafini A, Kuate C, Gelisse P, et al. Sleep before and after temporal lobe epilepsy surgery. Seizure 2012; 21:260-5.

Terzano MG, Parrino L, Anelli S, Boselli M, Clemens B. Effects of generalized interictal EEG discharges on sleep stability: assessment by means of cyclic alternating pattern. Epilepsia 1992; 33:317-26.

Sterpenich V, Schmidt C, Albouy G, et al. Memory reactivation during rapid eye movement sleep promotes its generalization and integration in cortical stores. Sleep 2014; 37:1061-75, 75A-75B.

Goulart LI, Pinto LR, Perlis ML, et al. Effects of different sleep deprivation protocols on sleep perception in healthy volunteers. In Press Corrected Proof Sleep Med 2014.

van Enkhuizen J, Acheson D, Risbrough V, Drummond S, Geyer MA, Young JW. Sleep deprivation impairs performance in the 5-choice continuous performance test: similarities between humans and mice. Behav Brain Res 2014; 261:40-8.

Hirotsu C, Matos G, Tufik S, Andersen ML. Changes in gene expression in the frontal cortex of rats with pilocarpine-induced status epilepticus after sleep deprivation. Epilepsy Behav. 2013; 27:378-84.

Vignatelli L, Bisulli F, Naldi I, et al. Excessive daytime sleepiness and subjective sleep quality in patients with nocturnal frontal lobe epilepsy: a case-control study. Epilepsia. 2006; 47 Suppl 5:73-7.

Barreto JR, Fernandes RM, Sakamoto AC. Correlation of sleep macrostructure parameters and idiopathic epilepsies. Arq Neuropsiquiat. 2002; 60:353-7.

Carrion MJ, Nunes ML, Martinez JV, Portuguez MW, da Costa JC. Evaluation of sleep quality in patients with refractory seizures who undergo epilepsy surgery. Epilepsy Behav 2010; 17:120-3.

Parrino L, De Paolis F, Milioli G, et al. Distinctive polysomnographic traits in nocturnal frontal lobe epilepsy. Epilepsia 2012; 53:1178-84.

Nobili L, Francione S, Mai R, et al. Surgical treatment of drug-resistant nocturnal frontal lobe epilepsy. Brain 2007; 130:561-73.

Diaz-Negrillo A. Influence of sleep and sleep deprivation on ictal and interictal epileptiform activity. Epilepsy Res Treat 2013; 2013:492524.

Ng M, Pavlova M. Why are seizures rare in rapid eye movement sleep? Review of the frequency of seizures in different sleep stages. Epilepsy Res Treat. 2013; 2013:932790.

Halasz P. How Sleep Activates Epileptic Networks? Epilepsy Res Treat 2013; 2013:425697.

Malow BA, Selwa LM, Ross D, Aldrich MS. Lateralizing value of interictal spikes on overnight sleep-EEG studies in temporal lobe epilepsy. Epilepsia 1999; 40:1587-92.

Malow BA, Aldrich MS. Localizing value of rapid eye movement sleep in temporal lobe epilepsy. Sleep Med 2000; 1:57-60.

Ochi A, Hung R, Weiss S, et al. Lateralized interictal epileptiform discharges during rapid eye movement sleep correlate with epileptogenic hemisphere in children with intractable epilepsy secondary to tuberous sclerosis complex. Epilepsia 2011; 52:1986-94.

Sammaritano M, Gigli GL, Gotman J. Interictal spiking during wakefulness and sleep and the localization of foci in temporal lobe epilepsy. Neurology 1991; 41:290-7.

Clemens Z, Janszky J, Clemens B, Szucs A, Halasz P. Factors affecting spiking related to sleep and wake states in temporal lobe epilepsy (TLE). Seizure 2005; 14:52-7.

Giorgi FS, Maestri M, Guida M, et al. Controversial issues on EEG after sleep deprivation for the diagnosis of epilepsy. Epilepsy Res Treat 2013; 2013:614685.

Giorgi FS, Perini D, Maestri M, et al. Usefulness of a simple sleep-deprived EEG protocol for epilepsy diagnosis in de novo subjects. Clin Neurophysiol 2013; 124:2101-7.

Badawy RA, Curatolo JM, Newton M, Berkovic SF, Macdonell RA. Sleep deprivation increases cortical excitability in epilepsy: syndrome-specific effects. Neurology 2006; 67:1018-22.

Piperidou C, Karlovasitou A, Triantafyllou N, et al. Influence of sleep disturbance on quality of life of patients with epilepsy. Seizure 2008; 17:588-94.

Manni R, Politini L, Sartori I, Ratti MT, Galimberti CA, Tartara A. Daytime sleepiness in epilepsy patients: evaluation by means of the Epworth sleepiness scale. J Neurol 2000; 247:716-7.

Malow BA, Bowes RJ, Lin X. Predictors of sleepiness in epilepsy patients. Sleep 1997; 20:1105-10.

Pizzatto R, Lin K, Watanabe N, et al. Excessive sleepiness and sleep patterns in patients with epilepsy: a case-control study. Epilepsy Behav 2013; 29:63-6.

Khatami R, Zutter D, Siegel A, Mathis J, Donati F, Bassetti CL. Sleep-wake habits and disorders in a series of 100 adult epilepsy patients--a prospective study. Seizure 2006; 15:299-306.

Maestri M, Giorgi FS, Pizzanelli C, et al. Daytime sleepiness in de novo untreated patients with epilepsy. Epilepsy Behav 2013; 29:344-8.

Malow BA, Fromes GA, Aldrich MS. Usefulness of polysomnography in epilepsy patients. Neurology 1997; 48:1389-94.

Malow BA, Levy K, Maturen K, Bowes R. Obstructive sleep apnea is common in medically refractory epilepsy patients. Neurology 2000; 55:1002-7.

Manni R, Tartara A. Evaluation of sleepiness in epilepsy. Clin Neurophysiol 2000; 111 Suppl 2:S111-4.

Touchon J, Baldy-Moulinier M, Billiard M, Besset A, Cadilhac J. Sleep organization and epilepsy. Epilepsy Res 1991; 2:73-81.

Roder-Wanner UU, Noachtar S, Wolf P. Response of polygraphic sleep to phenytoin treatment for epilepsy. A longitudinal study of immediate, short- and long-term effects. Acta Neurol Scand 1987; 76:157-67.

Ehrenberg BL, Eisensehr I, Corbett KE, Crowley PF, Walters AS. Valproate for sleep consolidation in periodic limb movement disorder. J Clin Psychopharmacol 2000; 20:574-8.

Karacan I, Orr W, Roth T, Kramer M, Thornby J, Bingham S, et al. Dose-related effects of phenobarbitone on human sleep-waking patterns. Br J Clin Pharmacol 1981; 12:303-13.

Sammaritano M, Sherwin A. Effect of anticonvulsants on sleep. Neurology 2000; 54:S16-24.

de Weerd A, de Haas S, Otte A, et al. Subjective sleep disturbance in patients with partial epilepsy: a questionnaire-based study on prevalence and impact on quality of life. Epilepsia 2004; 45:1397-404.

Zanzmera P, Shukla G, Gupta A, et al. Markedly disturbed sleep in medically refractory compared to controlled epilepsy - a clinical and polysomnography study. Seizure 2012; 21:487-90.

Malow BA, Weatherwax KJ, Chervin RD, et al. Identification and treatment of obstructive sleep apnea in adults and children with epilepsy: a prospective pilot study. Sleep Med 2003; 4:509-15.

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Publicado

30/08/2016

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Artigo de revisão

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A RELAÇÃO ENTRE SONO E EPILEPSIA: UMA REVISÃO SOBRE O TEMA. (2016). Arquivos Catarinenses De Medicina, 44(2), 26-36. https://revista.acm.org.br/arquivos/article/view/23

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