DESFECHOS MATERNO-FETAIS DE GESTANTES COM E SEM DIABETES MELLITUS GESTACIONAL

Authors

  • Rodrigo Ribeiro e Silva Universidade da Região de Joinville
  • Matheus Leite Ramos de Souza Universidade da Região de Joinville
  • Larissa Cano de Oliveira Universidade da Região de Joinville
  • Thiago Ribeiro e Silva Universidade Positivo
  • João Pedro de Paula Bertoli Pontifícia Universidade Católica do Paraná
  • Jean Carl Silva Universidade da Região de Joinville. Maternidade Darcy Vargas.

Keywords:

Diabetes Gestacional. Complicações na Gravidez. Assistência Perinatal.

Abstract

Resumo:

Objetivo: Comparar os desfechos materno-fetais de gestantes com e sem diabetes mellitus gestacional (DMG). Metodologia: Foi realizado um estudo tipo caso-controle. O grupo de estudo foi composto por gestantes com diagnóstico de diabetes gestacional e início de tratamento entre 13 e 33 semanas de gestação atendidas de abril de 2011 a fevereiro de 2016, comparado a um grupo de estudo de gestantes sem DMG atendidas de setembro de 2016 a fevereiro de 2017. Os desfechos primários avaliados foram presença de doença hipertensiva específica da gestação (DHEG), via de parto, presença de recém-nascido (RN) pequeno (PIG) e grande (GIG) para a idade gestacional, necessidade de unidade de terapia intensiva (UTI), Apgars baixos e óbito fetal. A análise estatística foi realizada através do cálculo de regressão logística multinomial, com nível de significância de 95% ajustado para fatores de confusão. Resultado: Foram avaliadas 663 gestantes portadoras de DMG e 1409 sem DMG. Após a análise de razão de chance, prematuridade (0,629 IC 95% 0,410-0,966) e presença de RNs PIG (0,345 IC 95% 0,200-0,596) diminuíram no grupo de diabéticas. Registrou-se um aumento da chance de nascimentos por cesariana (2,343 IC 95% 1,914-2,869) e de RNs GIG (1,969 IC 95% 1,397-2,773). Nas demais complicações na gravidez, não houve alteração (DHEG, óbito fetal, Apgars baixos e necessidade de UTI). Conclusão: O diagnóstico e o tratamento de DMG na assistência perinatal apresentam impacto positivo na redução de prematuridade e da presença de RNs PIG, entretanto, notou-se um aumento de nascimentos por cesariana e de RNs GIG.

References

Referências Bibliográficas:

Rastreamento e diagnóstico de diabetes mellitus gestacional no Brasil. 2016 [cited 2018 Dec 23]; Available from: http://iris.paho.org/xmlui/handle/123456789/34278?locale-attribute=pt

Coustan DR, Lowe LP, Metzger BE, Dyer AR, International Association of Diabetes and Pregnancy Study Groups. The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: paving the way for new diagnostic criteria for gestational diabetes mellitus. Am J Obstet Gynecol [Internet]. 2010 Jun [cited 2018 Dec 23];202(6):654.e1-654.e6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20510967

Langer O, Yogev Y, Most O, Xenakis EMJ. Gestational diabetes: The consequences of not treating. Am J Obstet Gynecol [Internet]. 2005 Apr [cited 2018 Dec 23];192(4):989–97. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15846171

Guyatt GH, Oxman AD, Kunz R, Vist GE, Falck-Ytter Y, Schünemann HJ, et al. What is “quality of evidence” and why is it important to clinicians? BMJ [Internet]. 2008 May 3 [cited 2018 Dec 23];336(7651):995–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18456631

Society of Maternal-Fetal Medicine (SMFM) Publications Committee. Electronic address: pubs@smfm.org. SMFM Statement: Pharmacological treatment of gestational diabetes. Am J Obstet Gynecol [Internet]. 2018 May 1 [cited 2018 Dec 23];218(5):B2–4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/29409848

Poolsup N, Suksomboon N, Amin M. Effect of Treatment of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis. Khamseh ME, editor. PLoS One [Internet]. 2014 Mar 21 [cited 2018 Dec 23];9(3):e92485. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24658089

Vários autores. Diretrizes da Sociedade Brasileira de Diabetes 2017-2018 / Organização José Egídio Paulo de Oliveira, Renan Magalhães Montenegro Junior, Sérgio Vencio. Clannad E, editor. São Paulo; 2017. 383 p.

Padayachee C. Exercise guidelines for gestational diabetes mellitus. World J Diabetes [Internet]. 2015 [cited 2019 Feb 19];6(8):1033. Available from: http://www.wjgnet.com/1948-9358/full/v6/i8/1033.htm

do Valle JB, Silva JC, Oliveira DS, Martins L, Lewandowski A, Horst W. Use of a clinical-laboratory score to guide treatment of gestational diabetes. Int J Gynecol Obstet. 2018;140(1):47–52.

Dode MAS de O, Santos I da S dos. Fatores de risco para diabetes mellitus gestacional na coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 2004. Cad Saude Publica [Internet]. 2009 May [cited 2018 Dec 23];25(5):1141–52. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2009000500021&lng=pt&tlng=pt

Farren M, Daly N, O’Higgins AC, McKeating A, Maguire PJ, Turner MJ. The interplay between maternal obesity and gestational diabetes mellitus. J Perinat Med [Internet]. 2015 Jan 1 [cited 2018 Dec 20];43(3):311–7. Available from: https://www.degruyter.com/view/j/jpme.2015.43.issue-3/jpm-2014-0272/jpm-2014-0272.xml

Ryu RJ, Hays KE, Hebert MF. Gestational diabetes mellitus management with oral hypoglycemic agents. Semin Perinatol [Internet]. 2014 Dec 1 [cited 2018 Dec 23];38(8):508–15. Available from: https://www.sciencedirect.com/science/article/pii/S0146000514001001?via%3Dihub

Viana LV, Gross JL, Azevedo MJ. Dietary Intervention in Patients With Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis of Randomized Clinical Trials on Maternal and Newborn Outcomes. Diabetes Care [Internet]. 2014 Dec 20 [cited 2018 Dec 23];37(12):3345–55. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25414390

Ghomian N, Vahed SHM, Firouz S, Yaghoubi MA, Mohebbi M, Sahebkar A. The efficacy of metformin compared with insulin in regulating blood glucose levels during gestational diabetes mellitus: A randomized clinical trial. J Cell Physiol [Internet]. 2018 Sep 7 [cited 2018 Dec 20]; Available from: http://doi.wiley.com/10.1002/jcp.27238

Spaulonci CP, Bernardes LS, Trindade TC, Zugaib M, Francisco RPV. Randomized trial of metformin vs insulin in the management of gestational diabetes. Am J Obstet Gynecol [Internet]. 2013 Jul [cited 2018 Dec 23];209(1):34.e1-34.e7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23524173

Zhen XM, Li X, Chen C. Longer-term outcomes in offspring of GDM mothers treated with metformin versus insulin. Diabetes Res Clin Pract [Internet]. 2018 Oct [cited 2019 Feb 25];144:82–92. Available from: http://www.ncbi.nlm.nih.gov/pubmed/30031048

Yogev, Chen, Hod, Coustan, Oats, McIntyre, et al. Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: preeclampsia. Am J Obstet Gynecol [Internet]. 2010 Mar [cited 2018 Dec 23];202(3):255.e1-255.e7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20207245

Romero R, Erez O, Hüttemann M, Maymon E, Panaitescu B, Conde-Agudelo A, et al. Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity. Am J Obstet Gynecol [Internet]. 2017 Sep 1 [cited 2018 Dec 23];217(3):282–302. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28619690

Zhao L-P, Sheng X-Y, Zhou S, Yang T, Ma L-Y, Zhou Y, et al. Metformin versus insulin for gestational diabetes mellitus: a meta-analysis. Br J Clin Pharmacol [Internet]. 2015 Nov [cited 2019 Feb 25];80(5):1224–34. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25925501

Deryabina EG, Yakornova G V., Pestryaeva LA, Sandyreva ND. Perinatal outcome in pregnancies complicated with gestational diabetes mellitus and very preterm birth: case–control study. Gynecol Endocrinol [Internet]. 2016 Sep 30 [cited 2018 Dec 20];32(sup2):52–5. Available from: https://www.tandfonline.com/doi/full/10.1080/09513590.2016.1232215

Zeki R, Oats JJN, Wang AY, Li Z, Homer CSE, Sullivan EA. Cesarean section and diabetes during pregnancy: An NSW population study using the Robson classification. J Obstet Gynaecol Res [Internet]. 2018 May 1 [cited 2018 Dec 20];44(5):890–8. Available from: http://doi.wiley.com/10.1111/jog.13605

Inocêncio G, Braga A, Lima T, Vieira B, Zulmira R, Carinhas M, et al. Which Factors Influence the Type of Delivery and Cesarean Section Rate in Women with Gestational Diabetes? J Reprod Med [Internet]. [cited 2018 Dec 20];60(11–12):529–34. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26775462

KC K, Shakya S, Zhang H. Gestational Diabetes Mellitus and Macrosomia: A Literature Review. Ann Nutr Metab [Internet]. 2015 [cited 2018 Dec 23];66(2):14–20. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26045324

Catalano PM, McIntyre HD, Cruickshank JK, McCance DR, Dyer AR, Metzger BE, et al. The Hyperglycemia and Adverse Pregnancy Outcome Study: Associations of GDM and obesity with pregnancy outcomes. Diabetes Care [Internet]. 2012 Apr 1 [cited 2018 Dec 23];35(4):780–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22357187

Sovio U, Murphy HR, Smith GCS. Accelerated Fetal Growth Prior to Diagnosis of Gestational Diabetes Mellitus: A Prospective Cohort Study of Nulliparous Women. Diabetes Care [Internet]. 2016 Jun [cited 2019 Jan 15];39(6):982–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27208333

Wahabi HA, Fayed AA, Alzeidan RA, Mandil AA. The independent effects of maternal obesity and gestational diabetes on the pregnancy outcomes. BMC Endocr Disord [Internet]. 2014 Jun 13 [cited 2018 Dec 20];14:47. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24923207

Leng J, Li W, Zhang S, Liu H, Wang L, Liu G, et al. GDM Women’s Pre-Pregnancy Overweight/Obesity and Gestational Weight Gain on Offspring Overweight Status. PLoS One [Internet]. 2015 [cited 2018 Dec 20];10(6):e0129536. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26098307

Zhang X-H, Qiu L-Q, Ye Y-H, Xu J. Chromosomal abnormalities: subgroup analysis by maternal age and perinatal features in zhejiang province of China, 2011–2015. Ital J Pediatr [Internet]. 2017 Dec 12 [cited 2019 Feb 7];43(1):47. Available from: http://ijponline.biomedcentral.com/articles/10.1186/s13052-017-0363-y

Andrade Souza F, Canisso IF, Perez Osório J, Osório JP. ALGUMAS PARTICULARIDADES NO ENVELHECIMENTO DO GAMETA FEMININO. Rev Acadêmica Ciência Anim [Internet]. 2009 Jul 15 [cited 2019 Feb 7];7(3):273. Available from: https://periodicos.pucpr.br/index.php/cienciaanimal/article/view/9963

Ovesen PG, Jensen DM, Damm P, Rasmussen S, Kesmodel US. Maternal and neonatal outcomes in pregnancies complicated by gestational diabetes. a nation-wide study. J Matern Neonatal Med [Internet]. 2015 Sep 22 [cited 2018 Dec 23];28(14):1720–4. Available from: http://www.tandfonline.com/doi/full/10.3109/14767058.2014.966677

Persson M, Fadl H, Hanson U, Pasupathy D. Disproportionate Body Composition and Neonatal Outcome in Offspring of Mothers With and Without Gestational Diabetes Mellitus. Diabetes Care [Internet]. 2013 Nov 1 [cited 2018 Dec 23];36(11):3543–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24159180

Jang HC, Cho NH, Min YK, Han IK, Jung KB, Metzger BE. Increased macrosomia and perinatal morbidity independent of maternal obesity and advanced age in Korean women with GDM. Diabetes Care [Internet]. 1997 Oct [cited 2018 Dec 20];20(10):1582–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9314639

Stotland NE, Caughey AB, Breed EM, Escobar GJ. Risk factors and obstetric complications associated with macrosomia. Int J Gynecol Obstet [Internet]. 2004 Dec [cited 2018 Dec 23];87(3):220–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15548393

Published

2019-09-20

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Artigo original

How to Cite

DESFECHOS MATERNO-FETAIS DE GESTANTES COM E SEM DIABETES MELLITUS GESTACIONAL. (2019). Arquivos Catarinenses De Medicina, 48(3), 79-92. https://revista.acm.org.br/arquivos/article/view/519

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