FATORES ASSOCIADOS À PREMATURIDADE EM GESTANTES PORTADORAS DO VÍRUS HIV EM UM ESTADO DO SUL DO BRASIL
Palavras-chave:
HIV. Prematuridade. Gestação.Resumo
A prematuridade é a segunda causa de morte infantil. Há certa evidência de possível associação entre infecção pelo vírus HIV e o trabalho de parto prematuro. Este estudo tem como objetivo analisar os fatores associados à prematuridade em gestantes portadoras do vírus HIV. Um estudo transversal foi realizado envolvendo 1.845 parturientes do ano de 2010 a 2015 no estado de Santa Catarina, com dados advindos de dois sistemas de informações de domínio público. Utilizou-se análise de regressão de Poisson com estimador robusto. As variáveis que apresentaram p < 0,25 foram incluídas em um modelo multivariado permanecendo aquelas com p < 0,05. A idade média das parturientes foi de 26 anos, a idade gestacional variou de 37 a 41 semanas e o peso médio do recém-nascido de 2.894g. Os resultados apontaram que a zona de moradia urbana [RP 0,91 (IC95% 0,85-0,96)], peso do recém-nascido menor de 2.500g [RP 0,67 (IC95% 0,62-0,72)] e Apgar do 1º minuto <7 [RP 0,90 (IC95% 0,83-0,98)] estiveram associados à menor ocorrência de trabalho de parto prematuro.
Referências
World Health Organization. Recommended definitions, terminology and format for statistical tables related to the perinatal period and use of a new certificate for cause of perinatal deaths. Acta Obste Gynecol Scand. 1977 Jan; 56:247-53.
Reis HL, Araújo KS, Ribeiro LP, et al. Preterm birth and fetal growth restriction in HIV infected brazilian pregnant women. Rev Inst Med Trop São Paulo. 2015 Mar; 57:111-20.
Watts D, Williams P, Kacanek D, et al. Combination antiretroviral use and preterm birth. J Infec Dis. 2013; 207:612-21.
Van den Broek NR, Jean-Baptiste R, Neilson JP. Factors associated with preterm, early preterm and late preterm birth in Malawi. PLoS One [Internet]. 2014 Mar [acesso em 2015 Ago 12];9(3):e90128. Disponível em: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940843/?to-ol=pubmeddoi:10.1371/journal.pone.0090128
Blencowe H, Cousens S, Oestergaard MZ, et al. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet. 2012 Jun; 379:2162-72.
Skyler JA, Patterson J, Ambler G, et al. Correlates and outcomes of preterm birth, low birth weight, and small for gestational age in HIV-exposed uninfected infants. BMC Pregnancy Childbirth [Internet]. 2014 Jan [acesso em 2015 Ago 15]; 14:7. Disponível em: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897882/?tool=pubmed.doi:10.1186/1471-2393-14-7
Montenegro C, Rezende J. Parto Pré-termo. In: Montenegro C, Rezende J. Rezende Obstetrícia.13. ed. Rio de Janeiro: Guanabara Koogan; 2014.
Olagbuji BN, Ezeanochie MC, Ande AB, et al. Obstetric and perinatal outcome in HIV positive women receiving HAART in urban Nigeria. Arch Gynecol and Obstet. 2010 Jun; 281:991-4.
Watts D, Williams P, Kacanek D, Griner R, Rich K, Hazra R, et al. Combination antiretroviral use and preterm birth. J Infect Dis 2013; 207(4):612-21.
Koss CA, Natureeba P, Plenty A, Luwedde F, Mwesigna J, Ades V, et al. Risk Factors for Preterm Birth Among HIV-Infected Pregnant Ugandan Women Randomized to Lopinavir/Ritonavir- or Efavirenz-Based Antiretroviral Therapy. JAIDS 2014; 67(2):128-35.
Van der Merkel K, Hoffman R, Black V, Chersich M, Coovadial A, Rees H. Birth outcomes in South African women receiving highly active antiretroviral therapy: a retrospective observational study. J Int AIDS Soc. 2011; 14:42.
Chen JY, Ribaudo HJ, Souda S, Parekh N, Ogwun A, Lockman S, et al. Highly Active Antiretroviral Therapy and Adverse Birth Outcomes Among HIV-Infected Women in Botswana. Infect Dis. 2012; 206(11):1695-705.
Oliveira H, Abreu TF, Evangelista LA, Farias IFA, Mercadante RTC, Garcia MFL. Pregnancy Outcome in HIV-1-infected Women Receiving Combination Antiretroviral Therapy Prior versus After Conception Sex Transm Infect 2009; 85(2):82.
Dean S, Bhutta ZA, Mason EM, et al. In: Born too soon: the global action report on preterm birth. Howson CP, Kinney MV, Lawn JE. Geneva: World Health Organization; 2012.
Joint United Nations Programme on HIV/AIDS (UNAIDS). Ending AIDS. Progress towards the 90–90–90 Targets - Global Aids Update. 2017.
Montenegro C, Rezende J. Doenças Infecciosas. In: Montenegro C, Rezende J. Rezende Obstetrícia Fundamental.13. ed. Rio de Janeiro: Guanabara Koogan; 2014.
Ministério da Saúde (Brasil). Secretaria da saúde. Boletim Epidemiológico: AIDS e DST. Ano V. 2015-2016.
Liu L, Johnson HL, Cousens S, et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012 Jun; 379:2151-61.
Xiao PL, Zhou YB, Yang CMX, et al. Association between maternal HIV infection and low birth weight and prematurity: a meta-analysis of cohort studies. BMC Pregnancy Childbirth. 2015; 15:246. doi: 10.1186/s12884-015-0684-z
Zash RM, Popoola OA, Stordal K, et al. Risk factors for mortality among hiv-exposed and hiv-unexposed infants admitted to a neonatal intensive care unit in Botswana. J Paediatr Child Health. 2014 Mar; 50: 189–95. Publicado online 2013 Dec 23. doi: 10.1111/jpc.12454
Feresu SA, Harlow SD, Woelk GB. Risk factors for low birthweight in zimbabwean women: a secondary data analysis. PLoS One. 2015; 10: e0129705. doi: 10.1371/journal.pone.0129705
Mehta S, Manji KP, Young AM, et al. Nutritional indicators of adverse pregnancy outcomes and mother-to-child transmission of HIV among HIV-infected women. Am J Clin Nutr. 2008 Jun; 87:1639–49.
Dadhwal V, Sharma KA, Khoiwal K, et al. Pregnancy outcomes in HIV-infected women: experience from a tertiary care center of India. Int J MCH AIDS. 2017;6(1):75-81. doi: 10.21106/ijma.196.
Mettle Fo, Doku-Amponsah K, Mensah EYD. Statistical analysis of retroviral (HIV) status and other maternal risk factors associated with low borth weight and low apgar score of infants: evidence from the RGreater Accra Regional Hospital. [Thesis (MPhil.)] - University of Ghana; 2015.
Dreyfuss ML, Msamanga GI, Spiegelman D, et al. Determinants of low birth weight among HIV-infected pregnant women in Tanzania. Am J Clin Nutr. Dec 2001. 74:814-826.
Asavapiriyanont S, Kasiwat S. Prevalence of low birthweight infants in HIV-infected women delivered in Rajavithi Hospital. J Med Assoc Thai. 2011 Mar;94 Suppl 2:S66-70.
Ezechi O, David A, Gab-Okafor CV, et al. Incidence of and socio-biologic risk factors for spontaneous preterm birth in HIV positive Nigerian women. BMC Pregnancy Childbirth. 2012. 12:93 https://doi.org/10.1186/1471-2393-12-93.
Hegyi T, Carbone T, Anwar M, et al. The apgar score and its components in the preterm infant. Pediatrics. 1998 Jan;101:77-81.
Naidoo M, Sartorius B, Tshimanga-Tshikala G. Maternal HIV infection and preterm delivery outcomes at an urban district hospital in KwaZulu-Natal. 2011. S Afr J Infect Dis. 2016; 31(1): 25-8. doi: 10.1080/23120053.2016.1118838
Habib NA, Daltveit AK, Bergsjø P, et al. Maternal HIV status and pregnancy outcomes in northeastern Tanzania: a registry-based study. BJOG. 2008; 115:616–24. doi:10.1111/j.1471-0528.2008.01672.
Arab, K., Spence, A. R., Czuzoj-Shulman, N., & Abenhaim, H. A. (2017). Pregnancy outcomes in HIV-positive women: a retrospective cohort study. Archives of Gynecology and Obstetrics, 295(3), 599–606. doi:10.1007/s00404-016-4271-y
Lopez, M., Figueras, F., Hernandez, S., Lonca, M., Garcia, R., Palacio, M., & Coll, O. (2012). Association of HIV infection with spontaneous and iatrogenic preterm delivery. AIDS, 26(1), 37–43.doi:10.1097/qad.0b013e32834db300
Kreitchmann R, Li S, Melo VH, et al., Predictors of adverse pregnancy outcomes in HIV infected women in Latin America and the Caribbean: a cohort study. BJOG. 2014 Nov;121: 1501–08. doi:10.1111/1471-0528.12680.
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Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
