ESTADO DA ARTE DO MECANISMO AUTOFÁGICO COMO ESTRATÉGIA TERAPÊUTICA NA CARDIOLOGIA
Keywords:
Autofagia, Doença cardiovascular, Inibição/Ativação da AutofagiaAbstract
A autofagia desempenha um papel fundamental na manutenção da função cardíaca e da homeostase vascular, além de se destacar também na patogênese de diversas doenças cardiovasculares (DCV). No entanto, a dinâmica do fluxo de autofagia parece diferir em cada um dos tipos de DCV, cuja patogênese pode estar intrinsecamente associada a sinais autofágicos distintos (efeito protetor ou patogênico). Aqui, discutimos abordagens de sucesso voltadas à regulação da iniciação da autofagia para abordar a terapia direcionada às doenças cardiovasculares.
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