SEVERIDADE DAS CRISES EPILÉPTICAS E QUALIDADE DE VIDA DOS PACIENTESCOM EPILEPSIA FARMACORRESISTENTE EM USO DE DIETA CETOGÊNICA
Keywords:
Epilepsia. Dieta Cetogênica. Qualidade de vida.Abstract
RESUMO
Objetivos: Analisar em uma população de pacientes brasileiros com Epilepsia Farmacorresistente (EFR) realizando DC se a severidade das crises piora a QV dos mesmos. Métodos: Estudo analítico observacional transversal. Dados clínico-demográficos foram obtidos dos pacientes, que responderam aos questionários GASE e SSQ para aferir a severidade da epilepsia, bem como a um inventário para diagnóstico de depressão e ansiedade (HADS-D e HADS-A) e QOLIE-31 para estimar a qualidade de vida. Resultados: Foram entrevistados 10 pacientes, no período de janeiro a setembro de 2019. A média de idade de 34,7 anos, 50% do sexo feminino e média de escolaridade de 11 anos. Os pacientes obtiveram pontuação média de 3,70 na escala GASE, 9,20 na HADS-A, 7,90 na HADS-D e 50,92 na escala QOLIE-31. Houve correlação estatisticamente significante entre as escalas HADS-A e HADS-D (r: 0,886, p=0.001) e entre HADS-A e QOLIE-31 (r: -0,649, p=0.042). Conclusão: A severidade das crises epilépticas em pacientes com EFR em uso de DC não pode ser correlacionada com a QV.
References
Gagliari RJ, Takayanagui OM. Tratado de Neurologia da Academia Brasileira de Neurologia. 2. ed. Rio de Janeiro: Elsevier, 2019.
Kwan P, Brodie MJ. Effectiveness of First Antiepileptic Drug. Epilepsia. 2001 Oct 29;42(10):1255-60.
Chen Z, Brodie MJ, Liew D, Kwan P. Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs. JAMA Neurol. 2018 Mar 1;75(3):279.
Kwan P, Arzimanoglou A, Berg AT, Brodie MJ, Allen Hauser W, Mathern G, et al. Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia. 2009 Nov 3;51(6):1069-77.
Nair DR. Management of Drug-Resistant Epilepsy. CONTINUUM: Lifelong Learning in Neurology. 2016 Feb;22(1, Epilepsy):157-72.
Martin K, Jackson CF, Levy RG, Cooper PN. Ketogenic diet and other dietary treatments for epilepsy. Cochrane Database of Systematic Reviews. 2016 Feb 9. Disponível em: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD001903.pub3/epdf/full. cesso em: 28 mar. 2021.
Martin-McGill KJ, Bresnahan R, Levy RG, Cooper PN. Ketogenic diets for drug-resistant epilepsy. Cochrane Database of Systematic Reviews. 2020 Jun 24. Disponível em: https://www.cochrane.org/CD001903/EPILEPSY_ketogenic-diets-drug-resistant-epilepsy. Acesso em: 28 mar. 2021.
Teoli D, Bhardwaj,A. Quality Of Life. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2021.
Baker GA, Nashef L, Hout BA. Current Issues in the Management of Epilepsy: The Impact of Frequent Seizures on Cost of Illness, Quality of Life, and Mortality. Epilepsia. 1997 Jan;38(s1):S1-S8.
Leidy NK, Elixhauser A, Vickrey B, Means E, Willian MK. Seizure frequency and the health-related quality of life of adults with epilepsy. Neurology. 1999 Jul 1;53(1):162.
Silva TId, Alonso NB, Azevedo AM, Westphal-Guitti AC, Migliorini RCVP, Marques CM, et al. Tradução e adaptação cultural da Seizure Severity Questionnaire: resultados preliminares. J epilepsy clin neurophysiol. 2006 Mar;12(1):41-7.
Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, et al. ILAE Official Report: A practical clinical definition of epilepsy. Epilepsia. 2014 Apr;55(4):475-82.
Cramer JA, Baker GA, Jacoby A. Development of a new seizure severity questionnaire: initial reliability and validity testing. Epilepsy Research. 2002 Feb;48(3):187-97.
Speechley KN, Sang X, Levin S, Zou GY, Eliasziw M, Smith ML, et al. Assessing severity of epilepsy in children: Preliminary evidence of validity and reliability of a single-item scale. Epilepsy & Behavior. 2008 Aug;13(2):337-42.
Cramer JA, Perrine K, Devinsky O, Bryant-Comstock L, Meador K, Hermann B. Development and Cross-Cultural Translations of a 31-Item Quality of Life in Epilepsy Inventory. Epilepsia. 1998 Jan;39(1):81-8.
Botega NJ, Pondé MP, Medeiros P, Lima MG, Guerreiro CAM.Validação da escala hospitalar de ansiedade e depressão (HAD) em pacientes epiléticos ambulatóriais. J. bras. psiquiatr. 1998 Jun;47(6):285–9.
Devinsky O, Penry JK. Quality of Life in Epilepsy: The Clinician's View. Epilepsia. 1993 Sep;34(s4):S4-S7.
Scott AJ, Sharpe L, Hunt C, Gandy M. Anxiety and depressive disorders in people with epilepsy: A meta-analysis. Epilepsia. 2017 Jun;58(6):973-82.
Cramer JA, Blum D, Reed M, Fanning K. The Influence of Comorbid Depression on Seizure Severity. Epilepsia. 2003 Dec;44(12):1578-84.
Tarulli A, Devinsky O, Alper K. Progression of Postictal to Interictal Psychosis. Epilepsia. 2002 Jan 12;42(11):1468-71.
Ridsdale L, Wojewodka G, Robinson E, Landau S, Noble A, Taylor S, et al. Characteristics associated with quality of life among people with drug-resistant epilepsy. J Neurol. 2017 Jun;264(6):1174-84.
Siarava E, Hyphantis T, Katsanos AH, Pelidou S, Kyritsis AP, Markoula S. Depression and quality of life in patients with epilepsy in Northwest Greece. Seizure. 2019 Mar;66:93-8.
Boylan LS, Devinsky O, Barry JJ, Ketter TA. Psychiatric uses of antiepileptic treatments. Epilepsy & Behavior. 2002 Oct;3(5):54-9.
Kwon O, Park S. What is the role of depressive symptoms among other predictors of quality of life in people with well-controlled epilepsy on monotherapy?. Epilepsy & Behavior. 2011 Mar;20(3):528-32.
Norsa’adah B, Zainab J, Knight A. The quality of life of people with epilepsy at a tertiary referral centre in Malaysia. Health and Quality of Life Outcomes. 2013;11(1):143.
Yue L, Yu P, Zhao D, Wu D, Zhu G, Wu X, et al. Determinants of quality of life in people with epilepsy and their gender differences. Epilepsy & Behavior. 2011 Dec;22(4):692-6.
Grant AC, Prus N, Nakhutina L. Factors affecting quality of life in epilepsy in a multi-ethnic urban population. Epilepsy & Behavior. 2013 May;27(2):283-5.
Chandra P, Ahmad F, Tripathi M, Padma M, Gaikwad S, Gupta A, et al. Health-related quality of life using QOLIE-31: Before and after epilepsy surgery a prospective study at a tertiary care center. Neurol India. 2007;55(4):343.
Guekht AB, Mitrokhina TV, Lebedeva AV, Dzugaeva FK, Milchakova LE, Lokshina OB, et al. Factors influencing on quality of life in people with epilepsy. Seizure. 2007 Mar;16(2):128-33.
Bala A, Szantroch M, Gleinert A, Rysz A, Marchel A. Differences in quality of life of women and men with drug-resistant epilepsy in Poland. Epilepsy & Behavior. 2016 Jul;60:94-8.
Gilliam FG, Fessler AJ, Baker G, Vahle V, Carter J, Attarian H. Systematic screening allows reduction of adverse antiepileptic drug effects: A randomized trial. Neurology. 2004 Jan 13;62(1):23-7.
Szaflarski M, Meckler JM, Privitera MD, Szaflarski JP. Quality of life in medication-resistant epilepsy: The effects of patient’s age, age at seizure onset, and disease duration. Epilepsy & Behavior. 2006 May;8(3):547-51.
Jacoby A, Baker GA. Quality-of-life trajectories in epilepsy: A review of the literature. Epilepsy & Behavior. 2008 May;12(4):557-71.
Additional Files
Published
Issue
Section
License
Copyright (c) 2022 Arquivos Catarinenses de Medicina
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
